Pnm-12: Can Stress Lead to Infertility?
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Abstract:
Background: The role that stress plays in infertility remains controversial and despite medical advances a large percentage of infertility remains unexplained. Clinicians and researchers consistently report that infertile women view infertility and its treatment as extremely stressful. Basic science has elucidated the linkages between the hypothalamic-pituitary axis (HPA) and hypothalamic-pituitary gonadal axis such that it is now accepted that physical stressors can perturb women’s menstrual cycles. What is less clear is whether psychological stress can have the same effect. This study performed to evaluate the relationship between stress and infertility. Materials and Methods: This study is a review article that is provided with library and internet resources. Results: Stress arousal may compromise the feedback regulation of the hypothalamo-pituitary-adrenal axis (HPA), releasing stress-related biomarkers and thereby affecting establishment of pregnancy. For the HPA axis, blood cortisol levels increase which subsequently results in an increase in salivary cortisol. The fact that both of these biomarkers can be detected in saliva makes them ideal for use in populationbased studies. Recent work suggests that psychological stressors produce a more pronounced alpha-amylase response than physical stressors and Higher levels of stress as measured by salivary alphaamylase are associated with a longer time-to-pregnancy (TTP) and an increased risk of infertility. Another side some study established severe depressive symptoms were significantly associated with increased infertility-related distress at both the individual and partner level. Conclusion: These results suggest that stress is a risk factor of infertility. Health professionals should explore the quality of social networks and encourage seeking positive support from family and partners.
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Journal title
volume 8 issue 2.5
pages 297- 297
publication date 2014-07-01
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